Description
Product Characteristics: This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A similar protein complex in rat is associated with RNA polymerase elongation factor II.
Target Information: VPS36, VPS22 (SNF8\, MIM 610904), and VPS25 (MIM 610907) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. VPS36, VPS22, and VPS25 are also associated in a multiprotein complex with RNA polymerase II elongation factor (ELL\, MIM 600284) (Slagsvold et al., 2005 [PubMed 15755741]\, Kamura et al., 2001 [PubMed 11278625]).[supplied by OMIM, Mar 2008]